Electronic ISSN 2287-0237

VOLUME

PSMA FOR PET IMAGING OF PROSTATE CANCER

SEPTEMBER 2018 - VOL.14 | REVIEWS ARTICLE

18F-fluorodeoxyglucose (FDG or 18F-FDG) is the most widely used radiotracer forPositron Emission Tomography/Computed Tomography (PET/CT) imaging. However,using FDG for PET/CT imaging in prostate cancer is limited because a large fractionof prostate cancer shows limited FDG uptake. Previously, radiolabeled choline derivativesuch as 18F-fluorocholine and 11C-choline were considered as a more suitable alternativeto FDG for prostate cancer imaging. They are used as PET tracers for staging andrestaging of prostate cancer. Although the specificity of radiolabeled choline is quitehigh, the sensitivity is rather poor. Currently, targeting the prostate specific membraneantigen (PSMA) with molecular imaging agents has been increasingly investigated.PSMA is expressed in most prostate cancer and it is an ideal target for diagnosis andtreatment. There are many PSMA agents available nowadays. This article will givebrief overview about PSMA ligands for PET imaging and therapy of prostate cancer.

Keywords :

PSMA, PSMA imaging, Ga-68 PSMA

Address Correspondence to author:

Ananya Ruangma, PhDOncology Imaging & Nuclear Medical Department,Wattanosoth Hospital,Soi Soonvijai 7, NewPetchburi Rd,Bangkok 10310, Thailand.email: ananya.ru@bangkokhospital.com

Received: May 22, 2018

Revision received: May 24, 2018

Accepted after revision: July 6, 2018

BKK Med J 2018;14(2): 95-100.

DOI: 10.31524/bkkmedj.2018.09.016

MEDIA
Figure 1: Small molecule PSMA inhibitors for prostate cancer studies
Figure 2: Example of small molecule PSMA ligands.
Figure 3: Example of commercial 68Ge/68Ga Generators.
Figure 4: Schematic presentation of the cross section of a column-based generator.
Figure 5: Schematic decay of 68Ge.
Figure 6: 18F-PSMA-1007 and 18F-DCFPyL.
Table 1: Comparison of 68Ga, 18F and 177Lu
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