This retrospective study aimed to explore clinical outcomes and risk factors associated with mortality and treatment failure among A. baumannii infected patients.
This retrospective study gathered the data of patients infected with A. baumannii, during the period from January 2014 to December 2015, admitted at Hua Hin hospital. Patient data reviewed included demographic data, antimicrobial regimens, antimicrobial susceptibility, length of hospitalization, source of infections, and clinical outcomes. The primary outcome measurements were in-hospital mortality and risk factors related to failure and mortality.
One hundred and forty-five patients were included in the study. Of our results, pneumonia was the most common site of infection (80.7%). The in-hospital mortality and treatment failure rates were 43.4% and 52.4%, respectively. For logistic regression analysis, shock was a statistically significant risk factor associated with treatment failure (adjusted odd ratios 3.10, 95%CI 1.21-7.97) and in-hospital mortality (aOR 4.96; 95%CI 1.74-14.14). Whereas age ≥ 65 years (aOR 2.21; 95% 1.06-4.64) was only associated with in-hospital mortality.
Septic shock and patients aged ≥ 65 years old were associated with unfavourable treatment outcomes in patients with A. baumannii infections. Thus, this critical condition needs to be addressed and measures taken to improve outcomes of A. baumannii treatment.
A. baumannii, mortality, treatment failure, combination therapy
Received: March 1, 2019
Revision received: March 18, 2019
Accepted after revision: May 27, 2019
BKK Med J 2019;15(2): 154-157.