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The common treatment of chronic infection from periprosthetic joint infection is two-stage revision arthroplasty. The first-stage revision will use an antibiotic-impregnated cement spacer to maintain alignment, prevent soft tissue contracture, and produce high local drug concentration. An inadequate of antibiotic elution may cause drug resistance. There are many factors that influence the elution of antibiotic from the bone cement spacer including the type of antibiotic used, the amount of antibiotic, the type of bone cement, the porosity of bone cement, and the mixing method. The preparation of a proper and effective antibiotic-impregnated  cement  spacer  can  help the treatment of periprosthetic joint infection to be successful.