Electronic ISSN 2287-0237

VOLUME

THE EVALUATION OF POTENTIAL SKIN SENSITIZATION AND COLLAGEN SYNTHESIS OF RATS RECEIVING PROTEOGLYCAN SERUM

FEBRUARY 2018 - VOL.14 | ORIGINAL ARTICLE

Received: Janaury 4, 2018    Revision received: Janaury 8, 2018     Accepted after revision: Janaury 11, 2018

BKK Med J 2018;14(1):1-4.

OBJECTIVE

The aim of this study was to evaluate potential skin sensitization and collagen synthesis of rats receiving proteoglycan (PG) serum.

MATERIAL AND METHODS

Eighteen rats were randomly divided into 3 groups equally and assigned to receive 1 ml of serum base (control), 1% PG and 2% PG applied to skin. Histological analysis was evaluated for potential skin sensitization and collagen synthesis on days 7, 14, 21 and 28.

RESULTS

Histological analysis showed that 1% PG and 2% PG accelerated collagen synthesis. The evaluation of potential skin sensitization, on day 7, 14, 21 and 28 of rat applied with 1% PG and 2% PG were not significantly different when compared to the control group.

CONCLUSION

This study demonstrated that PG serum accelerated collagen synthesis and low potential skin sensitization.

Keywords

proteoglycans, collagen synthesis, potential skin sensitization, Trichopoduspectoralis

Address Correspondence to author

Wannara Chuenwattana

Faculty of Science and Technology, Bansomdejchaopraya Rajabhat University,

1061 Isaraphab 15 Rd. Dhonburi, Bangkok 10600, Thailand.

email: doctor_too@yahoo.com

DOI:

10.31524/bkkmedj.2018.02.001

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