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An integrative review is an internationally accepted approach that is often used for identifying, analyzing, reporting, interpreting and drawing the theme conclusions from multiple studies. This study aimed to synthesize perspectives of the burden upon stroke caregivers. Data were collected from international databases. Qualitative studies reported the perceptions of the caregivers in caring for persons who had suffered a stroke. The search was limited to the English language; journal articles; age groups included all adults; quantitative studies or irrelevant articles were excluded. Eight articles relevant to the objective were included. The identified data were extracted from the results in the eight relevant sections and then ATLAS.ti 8 Software was used for the analysis of the qualitative studies. The results of this study were synthesized into three main themes: (1) the level of the caregiver burden; (2) the environmental factors of the burden, and (3) the related illnesses from the burden. Conclusion: The integrative review of qualitative studies about the burden endured by stroke caregivers arranged unique insights into the stroke caregiver perceptions and extracted their expressions of behavior into three themes about the burden. These findings could serve as a basis for creating a program to reduce the burden of stroke caregivers.